Depends what class and gear level. An Orc warlock should be able to easily fear-kite a big daddy with near impunity, the daddies of course having almost no resistance to magic/plasmids and are easily distracted and aren't really that hard to kill. I'd much rather face one than a SL/SL warlock.
I still would love to see a sequel follow the 'Bad' ending, where the splicers are set free upon the surface world - maybe a major Atlantic coast city. The MMO could set the spliced, Rapture faction against the surface, early-plasmid-adopter faction. Add generous doses of Atlas Shrugged and it could work.
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